Dr. Manabe is currently the Associate Director of Global Health Research and Innovation within the Johns Hopkins Center for
Global Health, a Professor of Medicine, International Health, and Molecular Microbiology and Immunology and a faculty member of both the Center for Tuberculosis Research and Center for Clinical Global Health Education.

From 2007 until 2012, she was the Head of Research at the Infectious Diseases Institute (IDI) in Kampala, Uganda where she built a strong research infrastructure (regulatory compliance, biostatistics, longitudinal cohorts, and the translational research lab to build basic science research) which has led to increased academic productivity and formal recognition of the IDI as a Research Center of Excellence. She also consolidated and built the research capacity building programs which have trained numerous Ugandan Masters, PhD, and Post-Doctoral Fellows within country. Her own research is in health systems strengthening, implementation science, and epidemiology particularly in the area of HIV-TB and other co-infections. She is dedicated to bringing frugal innovation in rapid and point-of-care diagnostics particularly for infectious diseases to resource-limited settings that will lead to diagnostic certainty and targeted treatment to slow the development of antimicrobial resistance.

Dr. Manabe is an author of more than 140 peer-reviewed publications. She obtained her undergraduate degree from Yale University and her MD from Columbia University College of Physicians and Surgeons. She joined the Johns Hopkins School of Medicine faculty in 1999 after completing her residency in internal medicine and fellowship in infectious diseases at Johns Hopkins Hospital.